Direct compression properties of microcrystalline cellulose and its silicified product

Silicified microcrystalline cellulose pdf

Effect of Lubricants on Flow Properties and Tablet Strength of Silicified Microcrystalline Cellulose

The effects of magnesium stearate, sodium lauryl sulphate (SLS) and talc as lubricants on some powder and tablet properties of silicified microcrystalline cellulose (SMCC) were studied. Single and binary blends of talc, magnesium stearate and SLS at 1% concentration were evaluated as flow modulators on SMCC. Influence of the lubricants on the powder and tablet properties of metronidazole was al...

Evaluation of Chitosan-Microcrystalline Cellulose Blends as Direct Compression Excipients

This study was aimed at evaluating chitosan-microcrystalline cellulose blends as direct compression excipients. Crab shell chitosan, α-lactose monohydrate, and microcrystalline cellulose powders were characterized. Blends of the microcrystalline cellulose and chitosan in ratios 9 : 1, 4 : 1, 2 : 1, and 1 : 1 as direct compression excipients were made to constitute 60% of metronidazole tablets. ...

Direct Compression Microcrystalline Cellulose Grade 12 versus Classic Grade 102

straightforward in terms of good manufacturing practice requirements than are wet granulation and dry compaction, the pharmaceutical industry is focusing increasingly on this process. Although coarse microcrystalline cellulose (MCC) grade 12 offers outstanding flow properties, the most commonly used grade for direct compression is the well-known fine grade 102. The reason for this preference is...

Microcrystalline cellulose, a direct compression binder in a quality by design environment--a review.

The ICH quality vision introduced the concept of quality by design (QbD), which requires a greater understanding of the raw material attributes, of process parameters, of their variability and their interactions. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compr...